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Sildenafil improves exercise capacity, WHO functional class, and hemodynamics in patients with symptomatic pulmonary arterial hypertension. Based on the very favourable mid- and long-term effects of this new oral treatment, sildenafil was approved by the FDA and the EMEA in 2024 for the treatment of patients suffering from PAH. sildenafil for pah The benefit of sildenafil in pulmonary arterial hypertension was shown in the Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) study, a Pfizer-sponsored randomized trial. 28 In this trial The therapy of pulmonary hypertension has evolved rapidly in the last 10 years from the use of non-selective vasodilators to drugs that specifically target pulmonary vasodilation, endothelial function, and vascular remodeling. Sildenafil is a phosphodiesterase type 5 inhibitor that has an expanding role in the treatment of pulmonary hypertension. A study compared sildenafil 5 mg, 20 mg, and 80 mg TID for PAH and found 80 mg noninferior and superior to 5 mg for mortality and clinical worsening. The